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SALVADOR 2.3: A Tool for Studying Mutation Rates

Qi Zheng
Organization: Texas A&M Health Science Center
Department: Epidemiology and Biostatistics
Revision date


The fluctuation experimental protocol pioneered by Luria and Delbruck in 1943 remains the preferred approach for estimating microbial mutation rates. SALVADOR is a package intended as a tool for estimating mutation rates using data generated under the Luria-Delbruck protocol. The package was originally designed for use in mutation research, but now it also appears to be a useful tool for educational purposes. SALVADOR 2.3 provides the user with all existing methods, classic estimators and recently developed ones. The focus of SALVADOR is on relatively new point and interval estimators that are strictly based on the likelihood principle. As an educational tool, SALVADOR offers functions that allow the user to simulate fluctuation experiments and to compute the probability mass functions of commonly used mutant distributions. SALVADOR 2.3 covers three formulations of the Luria-Delbruck mutation model (i.e., the Lea-Coulson formulation, the Haldane formulation, and the Bartlett formulation).

*Science > Biology

mutation rate, Luria-Delbruck experiment, likelihood principle
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readmeV2-3.txt (3.7 KB) - Text file
manualV2-3.nb (519.4 KB) - Mathematica Notebook
salvadorV2-3.m (94.3 KB) - Mathematica Package
salvadorV2-3.sal (128 KB) - Windows executable file
salvadorV2-3.tm (23.3 KB) - MathLink C file