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SALVADOR 2.1: A Tool for Studying Mutation Rates

Qi Zheng
Organization: Texas A&M Health Science Center
Department: Epidemiology and Biostatistics
Revision date


The fluctuation experimental protocol pioneered by Luria and Delbruck some sixty years ago remains the preferred approach to estimating mutation rates. SALVADOR 2.1 provides the user with all existing methods for estimating mutation rates using data from fluctuation experiments. Although the focus of SALVADOR is on point and interval estimators that are based on the maximum likelihood principle, SALVADOR also makes available methods that were popular in the past and are still of great historical interest today. As an educational tool, SALVADOR offers functions that allow the user to simulate fluctuation experiments and to compute the probability mass functions of commonly used mutant distributions. New in version 2.1 are estimation methods derived under Haldane's model that assumes synchronous cell growth.

*Science > Biology

Luria-Delbruck mutation model, mutation rate, maximum likelihood principle, point and interval estimation
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readmeV2.1.txt (3.4 KB) - Text file
manualV2.1.nb (404.4 KB) - Mathematica Notebook [for Mathematica 5.0]
salvadorV2.1.m (50.7 KB) - Mathematica Package [for Mathematica 5.0]
salvadorV2.exe (160 KB) - Windows executable file
salvadorV2.tm (10.9 KB) - C source for UNIX users