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SALVADOR: A Tool for Fluctuation Analysis

Qi Zheng
Organization: Texas A&M University Health Science Center
Department: Department of Epidemiology and Biostatistics
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Fluctuation analysis is a time-honored technique for estimating mutation rates. SALVADOR, a package written in a blend of the Mathematica and the C language, provides the user with a convenient tool for exploring on the computer various aspects of fluctuation analysis. Specifically, the package offers functions that allow the user to simulate fluctuation experiments, to compute the probability mass functions of commonly used mutant distributions, and to estimate mutation rates using real or simulated data. In addition to the maximum likelihood method, several other existing methods for estimating mutation rates are also included in SALVADOR. A unique feature of SALVADOR is the implementation of a new method for computing Fisher's information for the expected number of mutations, which can be used to construct confidence intervals for mutation rates.

*Science > Biology

fluctuation experiment, mutation rate estimation, Fisher's information, maximum likelihood estimation, confidence interval
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*SALVADOR 2.0: A Tool for Fluctuation Analysis   [in MathSource: Packages and Programs]
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readme.txt (2.8 KB) - Text file
manual.nb (132.4 KB) - Mathematica Notebook
salvador.exe (36.5 KB) - Windows executable file
salvador.m (13 KB) - Mathematica Package
salvador.tm (10.3 KB) - Unknown MIME type