 |
Many pharmacodynamic processes can be described by the nonlinear saturation kinetics that are most frequently based on the hyperbolic Michaelis-Menten equation. Thus, various timedependent solutions for drugs obeying such kinetics can be expressed in terms of the Lambert W(x)-omega function. However, unfortunately, computer programs that can perform the calculations for W(x) are not widely available. To avoid this problem, the replacement of the integrated Michaelis-Menten equation with an empiric integrated 1 – exp alternative model equation was proposed recently by Keller et al. (Ther Drug Monit. 2009;31:783–785), although, as shown here, it was not necessary.
|
|
For the newest resources, visit Wolfram Repositories and Archives »
