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Comparison of Annual and Biannual Mass Antibiotic Administration for Elimination of Infectious Trachoma

Muluken Melese
Wondu Alemayehu
Takele Lakew
Elizabeth Yi
Jenafir House
Jaya D. Chidambaram
Zhaoxia Zhou
Vicky Cevallos
Kathryn Ray
Kevin Cyrus Hong
Travis C. Porco
Isabella Phan
Ail Zaida
Bruce D. Gaynor
John P. Witcher
Thomas M. Lietman
Journal / Anthology

Journal of the American Medical Association
Year: 2008
Volume: 299
Issue: 7
Page range: 778-784

Context Treatment recommendations assume that repeated mass antibiotic distributions can control, but not eradicate or even locally eliminate, the ocular strains of chlamydia that cause trachoma. Elimination may be an important end point because of concern that infection will return to communities that have lost immunity to chlamydia after antibiotics are discontinued.

Objective To determine whether biannual treatment can eliminate ocular chlamydial infection from preschool children and to compare results with the World Health Organization–recommended annual treatment.

Design, Setting, and Participants A cluster-randomized clinical trial of biannual vs annual mass azithromycin administrations to all residents of 16 rural villages in the Gurage Zone, Ethiopia, from March 2003 to April 2005.

Interventions At scheduled treatments, all individuals aged 1 year or older were offered a single dose of oral azithromycin either annually or biannually.

Main Outcome Measure Village prevalence of ocular chlamydial infection and presence of elimination at 24 months in preschool children determined by polymerase chain reaction, correcting for baseline prevalence. Antibiotic treatments were performed after sample collections.

Results Overall, 14 897 of 16 403 eligible individuals (90.8%) received their scheduled treatment. In the villages in which residents were treated annually, the prevalence of infection in preschool children was reduced from a mean of 42.6% (range, 14.7%-56.4%) to 6.8% (range, 0.0%-22.0%) at 24 months. In the villages in which residents were treated biannually, infection was reduced from 31.6% pretreatment (range, 6.1%-48.6%) to 0.9% (range, 0.0%-4.8%) at 24 months. Biannual treatment was associated with a lower prevalence at 24 months (P = .03, adjusting for baseline prevalence). At 24 months, no infection could be identified in 6 of 8 of those treated biannually and in 1 of 8 of those treated annually (P = .049, adjusting for baseline prevalence).

Conclusion Local elimination of ocular chlamydial infection appears feasible even in the most severely affected areas, although it may require biannual mass antibiotic distributions at a high coverage level.

*Science > Medicine

antibacterial agents, antibiotic prophylaxis, azithromycin, child, chlamydia trachomatis, drug therapy, ethiopia, eye diseases, eye infections, trachoma, world health