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Modeling of 31P-NMR spectra of magnetically oriented phospholipid liposomes: A new analytical solution
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| Solid State Nuclear Magnetic Resonance |
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P-NMR spectroscopy is widely used for studies of phospholipid liposomes, a commonly used model of a biological membrane. For the correct analysis of 31P-NMR spectra of the liposomes it is necessary to take into account that they are deformed by the magnetic field of the spectrometer. The liposomes become ellipsoidal and this affects the lineshape of the spectrum. In the present communication we suggest a new analytical formula for modeling of 31P-NMR spectra of the prolate phospholipid liposomes. The formula assumes a Lorentzian broadening function and exactly ellipsoidal shape of the liposomes. Based on the formula a program called P-FIT is designed for the practical analysis of the experimental multicomponent spectra of the prolate liposomes. The versatility of the program developed in a Mathematica environment is demonstrated by simulations of a number of 31P-NMR spectra with different complexity. r 2005 Elsevier Inc. All rights reserved.
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P-NMR spectroscopy, Prolate phospholipid liposomes, deformation by the magnetic field, modeling of NMR spectra, analyticla formula for spectrum lineshape
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