Wolfram Library Archive

Courseware Demos MathSource Technical Notes
All Collections Articles Books Conference Proceedings

Dose Optimization of Proton and Heavy Ion Therapy Using Generalized Sampled Pattern Matching

Kiyoshi Yoda
Y. Saito
H. Sakamoto
Journal / Anthology

Phys. Med. Biol.
Year: 1997
Volume: 42
Page range: 2411-2420

We have proposed a new dose optimization method for proton and heavy ion therapy using generalized sampled pattern matching, where an optimal beam weight distribution for scanning is obtained as a solution. using water phantom models, one-dimensional lateral and depth dose distribution were separately optimized, each resulting in a uniform dose distribution within a target region and minimum dose fall-off to minimize undesired irradiation onto neighboring tissues. Subsequently, we have applied the technique to broad beam three-dimensional proton therapy, leading to a homogeneous dose distribution inside a target and minimized distal and lateral dose fall-off for most convex tumour shapes.

*Science > Biology