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distribution of the open and closed times (for the case of a single channel \
under study) or the time evolution of the total current flowing through a \
group of independent channels caused by a transient in the transmitter \
concentration.\nThe experimental findings for the open time distribution of \
single channels (exponential) and for the spectral density of the \
fluctuations of current flowing through an ensemble of channels (Lorentzian) \
are consistent with the assumption that the kinetics of these channels can be \
modeled as a Markov process. At any given time, the molecule is supposed to \
be in one of a small number of states such as \"singly liganded\", \"doubly \
liganded\", \"open\" or \"desensitized\", the transition rate constants \
between these states being constant or linear in the transmitter \
concentration (for those transitions involving the binding of a transmitter \
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" is a transition rate constant. If a channel state allows transitions to \
several target states, the respective lifetimes are computed and the \
transition associated with the shortest random lifetime is taken.\nThe \
following simulates the response of a single channel to a 1 ms, 1 mM pulse of \
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s
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p
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s
P
[(I/pA)] .02381 .61803 0 -4 Mshowa
p
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s
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