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SALVADOR 2.2: A Tool for Studying Mutation Rates
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| Organization: | Texas A&M Health Science Center |
| Department: | Epidemiology and Biostatistics |
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2008-01-18
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The fluctuation experimental protocol pioneered by Luria and Delbruck in 1943 remains the preferred approach for estimating microbial mutation rates. SALVADOR 2.2 provides the user with all existing methods for estimating mutation rates using data from fluctuation experiments. Although the focus of SALVADOR is on point and interval estimators that are based on the maximum likelihood principle, SALVADOR also makes available methods that were popular in the past and that are still of historical interest today. As an educational tool, SALVADOR offers functions that allow the user to simulate fluctuation experiments and to compute the probability mass functions of commonly used mutant distributions. SALVADOR 2.2 deals with three formulations of the Luria-Delbruck mutation model, i.e., the Lea-Coulson formulation, the Haldane formulation, and the Bartlett formulation.
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fluctuation test, mutation rate, Luria-Delbruck model
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| readmeV2-2.txt (3.6 KB) - Text file | | manualV2-2.nb (389.7 KB) - Mathematica Notebook [for Mathematica 6.0] | | salvadorV2-2.m (73.6 KB) - Mathematica Package | | salvadorV2-2.sal (124 KB) - Unknown MIME type | | salvadorV2-2.tm (20.6 KB) - Unknown MIME type |
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