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Title

The Power of Two Experimental Designs for Detecting Linkage Between a Marker Locus and a Locus Affecting a Quantitative Character in a Segregating Population
Author

Z. Luo
Journal / Anthology

Genetic and Selective Evolution
Year: 1993
Volume: 25
Page range: 249-261
Description

The statistical power of 2 experimental designs (backcrossing and intercrossing) for detecting linkage between a marker gene and a quantitative trait locus (QTL) in families derived from a segregating population is investigated. Formulae which relate power to the recombination frequency (r) between the genes, the genetical properties of the quantitative trait controlled by the QT. and the design parameters are developed. The reliability of some simplifying assumptions was confirmed by computer simulations. Application of these formulae has shown that the power of the 2 designs with population size of 1000 was < 20% when r was 0.3 for all heritabilities of single gene considered, few large families are better than many small families, and backcrossing is generally more efficient than intercrossing. The allele frequencies and dominance properties of the QTLs have important interactions in their effects on power.
Subjects

*Mathematics > Probability and Statistics
*Science > Biology