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Title

Mathematica program:Its use to simulate metabolic irreversible pathways and inhibition of the first enzyme of a pathway by its end product as visualized with the reservoir model
Authors

Francisco López-Cánovas
PaulaJ.F. Gomes
Antonio Sillero
Journal / Anthology

ComputersinBiologyandMedicine
Year: 2013
Volume: 43
Page range: 853–864
Description

The main objective of this report is to show the usefulness and versatility of the Mathematica program to simulate enzyme linear pathways and to depict the effect of changing the Vmax and/or Km valuesofoneor more enzymes on the course of the reaction. In addition, analysis of the different types of inhibition of the first enzyme of the pathway by its end product is viewed with the reservoir model for enzyme kinetics. All the data shown here are quantitatively related to the kinetic constants of the implicated enzymes. Particular attention has been paid to calculate the time needed to achieve half of the possible total synthesis of the final product of a metabolic pathway.
Subjects

*Applied Mathematics > Computer Science
*Science > Biology
*Science > Medicine