Wolfram Library Archive


Courseware Demos MathSource Technical Notes
All Collections Articles Books Conference Proceedings
Title

An Alternative Explicit Model Expression Equivalent to the Integrated Michaelis-Menten Equation and Its Application to Nonlinear Saturation Pharmacokinetics
Author

Marko Golicnik
Journal / Anthology

Therapeutic Drug Monitoring
Year: 2011
Volume: 33
Issue: 3
Page range: 362-365
Description

Many pharmacodynamic processes can be described by the nonlinear saturation kinetics that are most frequently based on the hyperbolic Michaelis-Menten equation. Thus, various timedependent solutions for drugs obeying such kinetics can be expressed in terms of the Lambert W(x)-omega function. However, unfortunately, computer programs that can perform the calculations for W(x) are not widely available. To avoid this problem, the replacement of the integrated Michaelis-Menten equation with an empiric integrated 1 – exp alternative model equation was proposed recently by Keller et al. (Ther Drug Monit. 2009;31:783–785), although, as shown here, it was not necessary.
Subject

*Unclassified