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ALASKA: A Mathematica Package for Two-State Kinetic Analysis of Protein Folding Reactions

R. Burton
R. Busby
T. Oas
Journal / Anthology

Journal of Biomolecular NMR
Year: 1998
Volume: 11
Page range: 355-360

A Mathematica package (ALASKA) has been developed to simplify the measurement of protein folding kinetics by analysis of ^1H NMR lineshape analysis. This package reads NMR data in ASCII format and can simulate an aromatic ^1NMR spectrum with or without lineshape broadening from chemical exchange. We describe the analysis of a urea denaturation series of a fast-folding protein, the G46A/G48A variant of monomeric l repressor.

*Science > Biology